This book provides a detailed and insightful exploration of liposomal drug delivery systems, a rapidly evolving technology in modern pharmaceutics. Designed for pharmacy students, formulation scientists, researchers, and regulatory professionals, the book addresses both theoretical principles and practical applications, bridging academic learning with industrial practice.

Starting with an introduction to liposomal drug delivery, the book explores the design, structure, and functional role of liposomes in enhancing the therapeutic profile of drugs. Readers are guided through the selection of excipients, formulation strategies, and the manufacturing processes involved, ranging from laboratory-scale development to commercial-scale production.

Key chapters focus on methods of drug loading, analytical characterization, and Quality by Design (QbD)-based formulation approaches. The book also covers targeted and long-acting liposomal systems, highlighting their significance in achieving site-specific delivery and prolonged drug action, particularly for cancer, infectious diseases, and inflammatory disorders.

The text further explores real-world challenges in sterilization, stability studies, and shelf-life determination, which are critical for regulatory approval and product success. Discussions on pharmacokinetics and pharmacodynamics (PK/PD) offer insights into how liposomal carriers influence drug absorption, distribution, and therapeutic outcomes.

The final chapter provides a concise overview of regulatory guidelines and compliance requirements, preparing readers for the translational journey from lab innovation to market-ready liposomal products. \n \nComprehensive and current, this book is a valuable reference for anyone engaged in drug delivery research, formulation development, or regulatory affairs seeking to advance in the field of nanomedicine and lipid-based drug carriers.

Dr. Bhupendra G Prajapati is a researcher and educator with expertise in pharmaceutical sciences and drug delivery. He holds a Ph.D. in Pharmaceutical Sciences from Hemchandracharya North Gujarat University, Patan. Dr. Prajapati’s career includes professorships at Shree S.K. Patel College of Pharmaceutical Education and Research, Ganpat University, India, and Silpakorn University, Thailand. His research focuses on the development of innovative drug delivery systems, particularly lipid-based formulations like liposomes, as well as biopolymers and nanoparticles. He is a prolific author with a strong record of publications in peer-reviewed journals, and contributions to edited books and book chapters. Dr. Prajapati has been recognized for his scholarly work, including the MDPI Pharmaceutics 2022 Outstanding Reviewer Award.

Dr. Dignesh Khunt is an Assistant Professor in the Department of Pharmaceutics at the School of Pharmacy, Gujarat Technological University, Gandhinagar, India. He holds a Ph.D. in Pharmaceutical Sciences from NIPER-Ahmedabad and an M.Pharm in Pharmaceutics. With over 10 years of experience in pharmaceutical research, his primary focus lies in liquid-based drug formulation, including microemulsions, topical formulations, oral liquids, and depot injectables. Dr. Khunt has published more than 30 research articles in renowned international journals and holds 2 patents related to pharmaceutical innovations. He actively serves as a reviewer for over 10 reputed journals, contributing to the global research community. His expertise in pharmaceutical technology makes him a recognized figure in both academia and industry, with a strong commitment to advancing the field of pharmaceutical sciences.
 

Chapter 1.Introduction of Liposomal Drug Delivery Eknath D. Ahire
Chapter 2.Liposome Formulations: Excipients and Challenges Nidhi N. Patel and Janki Patel
Chapter 3.Manufacturing Processes of Liposome: From Lab Scale to Industrial Scale Eknath D. Ahire,Kalarav V Makwana,Sagar Salaveand Bhavesh Bhavsar
Chapter 4.Different Methods of Drug Loading and Their Challenges Chintan Aundhia, Ghanshyam Parmar, Chitrali Talele, Mamta Kumari and Rahul Trivedi
Chapter 5.Analytical Characterization of Liposomal Formulation Dignesh Khunt, Megha Patil, Denisha Gadhiya, Bhupendra G Prajapati, Alpesh Patel and Brijesh M. Shah
Chapter 6.Role of QbD based Approaches in Formulation and Development of Liposomal Formulation Hitesh B. Katariya, Shivani N. Jani, Krunal K. Detholia, Umang R. Varia and Mukesh B. Jadeja
Chapter 7.Targeted Liposomal Drug Delivery Geetha Jyothi Vaskuri, Sagar Salave, Tanuja Tummala,Dignesh Khunt, Jill Kavaiya, Dhruvil Radadiya and Derajram Benival
Chapter 8.Challenges and Solutions in Sterilization of Liposomal Formulations Dhwani Rana, Derajram Benival, Megha Patel, Dasharath M. Patel and Sanjay P. Chauhan
Chapter 9.Stability Studies and Shelf-Life Determination of Liposomal Formulations Devesh U Kapoor and Bhupendra G Prajapati
Chapter 10.Pharmacokinetics and Pharmacodynamic Studies of Liposomal Formulation Dhwani Rana, Derajram Benival, Sagar Salave, Chintan Vora and Bhupendra G Prajapati
Chapter 11.Regulatory Considerations for Liposomal Formulations Ravi Patel, Aksha Vhora, Rucha Patel, Dhwani Rana and Dignesh Khunt