The book is a comprehensive, multidisciplinary volume addressing one of the most pressing global health threats of our time. The book presents an in-depth exploration of AMR across humans, animals, food systems, and the environment, aligning with national and international One Health priorities.

Organized into five thematic units, this volume covers the fundamentals of AMR, mechanisms of resistance, and major drivers shaping its emergence. It provides detailed insights into both conventional and advanced diagnostic approaches, including multiomics and bioinformatics. A significant portion of the book is devoted to innovative technologies and alternative therapies—nanotechnology, phage therapy, RNA-based therapeutics, CRISPR-Cas systems, immunotherapeutics, natural products, and AI/ML-driven solutions.

Sector-specific chapters highlight AMR in veterinary practice, aquaculture, wildlife, food chains, human healthcare facilities, and environmental reservoirs. The book concludes with robust One Health strategies necessary for surveillance, stewardship, and long-term containment.

With contributions from leading researchers across India, this book serves as a valuable resource for students, academicians, veterinarians, medical professionals, public health experts, policymakers, and researchers working in microbiology, life sciences, food safety, and environmental sciences. It is designed to support evidence-based decision-making, capacity building, and future research for combating AMR.

Dr. Nidhi Rawat holds an M.V.Sc. in Veterinary Microbiology from Indira Gandhi Krishi Vishwavidyalaya (IGKV), Raipur, and a Ph.D. in Veterinary Science from DSVC Kamdhenu Vishwavidyalaya (DSVCKV), Durg. Her core areas of expertise include microbial diagnostics, zoonotic diseases, antimicrobial resistance, and immunology. Dr. Rawat has made significant contributions to translational veterinary research and laboratory animal experimentation. She is an active member of the Institutional Animal Ethics Committee (IAEC) and the Laboratory Animal Scientists' Association (LASA). Her research has been widely published and nationally recognized, earning her multiple accolades. Currently, Dr. Rawat serves as the National Convenor of the Women’s Wing of the Indian Veterinary Association (IVA) and is a member of Animal Welfare committee of the Federation of Asian Veterinary Associations (FAVA). In addition to her research endeavors, she is actively engaged in teaching, mentoring, and curriculum development, with a strong emphasis on student involvement and the promotion of ethical practices in animal science.

Dr. Chandrahas Sannat has been working as Assistant Professor in the Department of Veterinary Microbiology at College of Veterinary Science & Animal Husbandry, Anjora, Durg, Chhattisgarh, India. He is actively involved in teaching, research, and extension activities, demonstrating his commitment to education, research, and community outreach. He has been awarded Chancellor’s Gold Medal for excellence in M.V.Sc. (Veterinary Microbiology). He has dedicated 13 years to researching antimicrobial resistance surveillance of ESKAPE pathogens and developing strategies for containment. He has authored over 20 research papers on antimicrobial resistance and a book on Foodborne Diseases.

Dr. Nitin E. Gade is a veterinary scientist with a strong academic background, holding his B.V.Sc. & A.H. from Bombay Veterinary College and Masters and Doctoral degree from the Indian Veterinary Research Institute (IVRI), Izatnagar. He is a recipient of several national fellowships and has qualified ICAR and CSIR-UGC NET. Currently an Assistant Professor at the College of Veterinary Science & Animal Husbandry, Anjora, Dr. Gade is actively engaged in teaching, student mentorship, and academic activities. His research focuses on stem cell biology and regenerative medicine, where he has led and collaborated on multiple funded projects. Dr. Gade has several scientific publications, numerous book chapters, and has presented at national and international conferences. A recipient of the J.N. Pandey Award for research excellence, he is also involved in academic administration and institutional development, contributing significantly to the advancement of veterinary education and research.

Preface
UNIT I: Introduction to Antimicrobial Resistance (AMR)
Chapter 1. Antimicrobial Resistance – An Overview Nidhi Rawat and Chandrahas Sannat
Chapter 2 Mechanisms of Antimicrobial Resistance Syamantak Mani Tripathi
Chapter 3 The Drivers and Determinants of Antimicrobial Resistance in the Veterinary Sector of India  Kishan Kumar Sharma, Harshadkumar C. Chauhan, Sandipkumar S. Patel and Sushil Kumar Mohapatra
Chapter 4 Antimicrobial Resistance and Risk Communication Prejit
Chapter 5 Antimicrobial Resistance and Pharmaceutical Industry: Risk and Responsibilities
Arun Atrey, D J Kalita and Jyotika Sangale
UNIT II: AMR Diagnostic Methods
Chapter 6 Conventional Methods for Antimicrobial Resistance Detection: Principles, Applications, and Global Relevance Sunpreet Kaur, Himanshu Singh Bisht & Balbeer Singh Dhami
Chapter 7 Mass Spectrometry Based Multiomics and Bioinformatics for AMR Research
Barkha Gupta, Shubham Kaushik, G.S. Gottam and Tribhuwan Sharma
UNIT III: Alternative Therapies and Innovations to Combat Antimicrobial Resistance
Chapter 8 Current Approaches for Drug Development and Antibiotic Combination Therapy
Shraddha Nety, Shweta Jain, Jyothi Vidyadharan and Aalisha
Chapter 9 Nanotechnology Based Drug Delivery Systems and Artificial Intelligence: Synergizing Technology for Antimicrobial Resistance (AMR) Solutions Divya Sahu, Lokendra Singh Rathor, ManjuRawat Singh, Deependra Singh
Chapter 10 Exploring Natural Products As a Promising Approach to Combat Anti-Microbial Resistance Pushpendra Kumar, Harkesh Dadsena, Chhavi Rahangdale, Lokprabha Hirwani, Bhoomika Swarnkar, Abhishek Nand, Yashika Israni, Umakant Sahu, Shabir Kumar Anant, Amber Vyas and Vishal Jain
Chapter 11 Antibiofilm Agents in AMR Containment Sunain Gupta and Dugeshwar Karley
Chapter 12 The Antimicrobial Effects of Polyherbal Formulation Sinha Chandreshwar Prasad, Kaser Nitesh and Rakesh Mishra
Chapter 13 Endophytes as an Alternative to Antimicrobials Anju Nayak, Poonam Shakya,Vandana Gupta, Sanjay Shukla, Joycee Jogi and Mahendra Singh
Chapter 14 Bacteriophage: A Promising Alternative Against Antimicrobial Resistance Bandita Panigrahi, Deepti Narang and Kalyani Panigrahi
Chapter 15 Synergistic Action of Bacteriophage – Antimicrobial Peptide Therapies in AMR Infections: Pharmacokinetic and Pharmacodynamic Challenges B. Dhanvandhini
Chapter 16 Effect of Phytobiotic Feed Supplements Ramchandra Ramteke1, M.K.Gendley and O.P. Dinani
Chapter 17 Vaccines and Immunotherapeutics to Combat Antimicrobial Resistance Rajesh Kumar, Mansi Bisht, Saumya Joshi, Shradha Sneh and Anuj Tewari
Chapter 18 Effective Therapeutic Value of Ayurveda Rakesh Mishra
Chapter 19 RNA Based Therapies to Combat Antimicrobial Resistance Ashutosh Tiwari, Namita Shukla, R. C. Ramteke, Deepti K. Bara, Dhananjay Jolhe, Shivesh Deshmukh, Jagriti Krishan, B. P. S. Kanwar, Rakesh Mishra, R.K. Gadpayle and Sabir Anant
Chapter 20 Harnessing Crispr-Cas Systems to Address Antimicrobial Resistance Himanshu Singh Bisht and Sunpreet Kaur
Chapter 21 Artificial Intelligence and Machine Learning in AMR Mitigation Ankit Kumar Singh and Dr Rakesh Mishra
UNIT IV: Sector Specific Antimicrobial Resistance Surveillance and Containment
Chapter 22 Molecular Profiling of Eskape Pathogens in Humans and AMR Surveillance in Animals Sabia Qureshi, Zahid Kashoo, Mir Nadeem Hassan, Pervaiz Dar, Muddasir S banday, Gulzar Badroo, Shaheen Farooq, Md. Isfaqul Hussain, Anjum Farhana, Lenah Bashir, Nahid Nehvi,Ram Kumar Pandit, Faheem ud din, Mahrukh Hafiz, Najeebul Tarfain and Hashir Manzoor
Chapter 23 Infection Prevention and Control in Critical Human Health Care Facilities Anil Kumar Singh
Chapter 24 Impact of Antimicrobial Resistance on Physical and Health Fitnes
Shabir Kumar Anant, Rajkumar Gadpayle, Ramchandra Ramteke, Shivesh Deshmukh & Ashutosh Tiwari
Chapter 25 Energy Healing & Ayush Veterinary Care for Mitigation of AMR Bimal Kumar Choudhury
Chapter 26 Drug Resistance in Haemoprotozoan Parasites: Current Status and Possible Mitigation Strategies K. R. Baghel, Savita Bisen, I. L. Raj, C. Sannat, N. Rawat, H. K. Ratre and S. Pal
Chapter 27 Antimicrobial Resistance in Equines: A Growing Threat From Equine Practitioners Perspective Rajkumar Gadpayle, V. N. Khune, Rupal Pathak, Ramchandra Ramteke and Shabir Kumar Anant
Chapter 28 Silent Spread of ESBL Producing E. Coli in Wild Animals: One Health Concern J. Singh, N. Rawat, C.Sannat, N.E.Gade, L.Kurrey and P. Kashyap
Chapter 29 Antimicrobial Resistance in Environment: Surveillance and Containment S. R. Warke and Mehak Tikoo
Chapter 30 Antimicrobial Resistance in Aquaculture: The Indian Concern P. Swain, S.N. Sahoo, P. Priyadarshani, and A.K. Pradhan
Chapter 31 Antimicrobial Resistance in Food Chain: Status, Transmission Routes Anil Patyal, Shriya Rawat, Sanjay Shakya, Piyush Tomar, Anjay, Subhash Kumar Verma, Chandrahas Sannat and Choodamani Chandrakar
Chapter 32 Antibiotic Residues in The Food: Driving Forces Behind Antimicrobial Resistance and One Health Challenge Seuli Saha Roy, P. Kaushik, Anjay and Bhoomika
Chapter 33 Recent Advances in Application of Natural Antimicrobials for Improving Quality and Safety of Meat and Meat Products Vandita Mishra, Pragati Hazarika, Rohit Kumar Jaiswal, B. Gowtham Prasad, H. Lalawmpuii
UNIT V: One Health Approach against Antimicrobial Resistance
Chapter 34 One Health: The Spur Begins Sandeep P. Chaudhari and Shilpshri V. Shinde
Chapter 35 NDDB’s One Health Model for AMR Containment A V Harikumar, Pankaj Dutta, Sagar Shroff and Keshank Dave
Chapter 36 Strengthening One Health Approach to Combat AMR D. Rani Prameela