The book presents an integrated and forward-looking exploration of emerging biological risks at the human–animal–environment interface. Structured across three thematic parts, the book brings together contemporary research, policy perspectives, and applied frameworks essential for understanding and managing complex health challenges through the One Health approach.

Part I focuses on microbial and viral frontiers, addressing preparedness for future zoonotic viruses, spillover dynamics influenced by climate change, and model diseases such as rabies and lumpy skin disease. Cutting-edge topics including omics-driven diagnostics, multi-epitope vaccine design, and the role of small ruminants in nutrition under infectious disease pressure are critically examined, highlighting innovation and resilience in One Health systems.

Part II is devoted to antimicrobial resistance (AMR), covering molecular mechanisms such as integrons, AMR in enteric bacteria, and comprehensive stewardship strategies. The section emphasizes systems thinking and end-to-end stewardship across human, veterinary, and environmental sectors.

Part III addresses food safety, policy, and implementation pathways, with chapters on bacteriophages, natural antimicrobials, food systems as drivers of viral spillover, leptospirosis control, and India-specific One Health policies and pandemic preparedness.

Written for postgraduate students, researchers, policymakers, veterinarians, public health professionals, and food safety experts, the book aligns with global and Indian One Health priorities, offering actionable insights for preparedness, prevention, and sustainable health governance.

Siddharth Gautam: Scientist  Division of Virology, ICAR–Indian Veterinary Research Institute (IVRI) Mukteshwar-263 138, Uttarakhand (India)

Karam Chand: Principal Scientist Division of Virology, ICAR–Indian Veterinary Research Institute (IVRI) Mukteshwar-263 138, Uttarakhand (India)

Yashpal Singh Malik: Joint-Director, ICAR–Indian Veterinary Research Institute (IVRI)  Mukteshwar-263 138, Uttarakhand (India)

Triveni Dutt: Director ICAR–Indian Veterinary Research Institute (IVRI) , Izatnagar 243 122, Uttar Pradesh (India)

Part I: Microbial and Viral Frontiers in One Health  

1.  Preparedness for Future Zoonotic Viruses

2.  Zoonotic Diseases and Spillover Events: Understanding Emergence Dynamics and the Critical Role of Climate Change

3.  An Overview of Lumpy Skin Disease with Respect to One Health Approach.

4.  ‘Rabies in One Health’ as a model

5.  Omics and Innovations in Viral Disease Diagnostics

6  Designing Multi Epitope Vaccines Against Emerging and Re-Emerging Human Viruses

7.  Harnessing the Nutritional Potential of Small Ruminants Amid Infectious Disease Challenge: A One Health Perspective

Part II — Antimicrobial Resistance and Stewardship

8.  Antimicrobial Resistance in Enteric Bacteria from Ducks: Molecular Insights and One Health Implications

9.  Integrons: Genetic Architects of Antimicrobial Resistance

10.  Antimicrobial Resistance 

11.  Combating Antimicrobial Resistance through One Health: From Systems Thinking to End-to-End Stewardship

Part III — Food Safety, Policy, and Implementation Pathways

12.  Role of Bacteriophage in Ensuring Food Safety in the Era of One Health 

13.  Reinventing Food Safety: Natural Solutions for the Antimicrobial Resistance Era

14.  Food Systems as Drivers of Species Spillover of Animal Viruses

15.  Bridging Boundaries: Integrated One Health Approach to the Control and Management of Leptospirosis

16.  One Health Policies in India:Animal Husbandry Perspective

17.  Pandemic Preparedness through One Health in India: Challenges, Progress and Future Directions